This site came about largely because TDF (Tenofovir Disoproxil Fumarate) medication can be toxic, and the new TAF (Tenofovir Alafenamide) medication is much safer, yet access to TAF based PrEP, HIV & HBV medication is currently problematic for many patients. Tenoforvir in itself is a great drug, unfortunately, the TDF form can cause bone and kidney toxicity and this tends to get worse over time. As a backbone drug many patients have taken it for long periods. 

With new medications like TAF infinitely preferable to TDF due to the significant reduction in bone and kidney side effects, we think anyone taking TDF based drugs for PrEP, HIV, or HBV should be seriously considering switching to TAF based ones. TAF is used at a much lower dose and has been shown to be equally effective while being much less toxic.

Atripla® (EFZ/FTC/TDF) has done a great job for many years but is getting a bit long in the tooth. Over the next few years it will be replaced as the #1 treatment of choice by Dolutegravir/FTC/TAF – and for good reasons such as getting rid of the TDF issues and the drug drug interactions that plague EFZ. At the moment DTG/FTC/TAF is not easily available but it can be sourced as a 2 pill combination. This is particularly important for patients who have been on TDF base HAART for many years.

FixHIV makes it easy for patients to access the new safer more effective medications for affordable prices*. We do that by sourcing high quality licensed generic medications from proven U.S. and Indian pharmaceutical companies, such as Mylan (USA), Natco, Hetero, and Cipla (India). All these generic drug companies have licensing agreements with all major originator pharmaceutical companies covering the vast majority of drugs (example here) which confirms the quality of their generic medicines.

TAF vs TDF toxicity
TAF vs TDF
TAF vs TDF toxicity
TAF vs TDF